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I. Cole, M.B.A., M.B.B.S., M.H.S.

Co-Director, Texas Tech University Health Sciences Center School of Medicine

A4769 P1356 P1344 Comparative Analysis of Oxidative Potential of Oil-Sands Secondary Organic Aerosol with Oxidative Stress and Inflammatory Response in Human Airway Epithelial Cells/X diabetes 1 vs 2 generic duetact 17mg on line. A4782 Increased Neutrophil-Platelet Interactions in Alpha-1 Antitrypsin Deficient Individuals Is Corrected Post Augmentation Therapy/N diabetes type 1 vs type 2 symptoms buy 16mg duetact otc. A4784 Development of an Automated Metered Dose Inhaler to Deliver Fluticasone to Rats and Examine the Effects of Corticosteroids on Upper Airway Function and Structure/N diabetes mellitus news buy duetact 17 mg cheap. A4772 Transcriptomic Profiling of Macrophage Subsets in Inflammatory Lung Disease/E managing diabetes 811 buy 16mg duetact mastercard. A4775 Evaluating the Sensitivity and Specificity of Neatstik Technology Compared to an Activity-Based Immunoassay in Sputum Samples/S. A4776 Lipids as Modifiable Risk Factors of Environmental Lung Disease: A Systematic Review of the Good, the Bad and the Misunderstood/E. A4778 Bronchoalveolar Lavage Cytokine Analysis in Deployment-Related Chronic Respiratory Symptoms/J. Discussion: 11:15-12:00: authors will be present for individual discussion 12:00-1:00: authors will be present for discussion with assigned facilitators Facilitators: R. A4780 the information contained in this program is up to date as of April 16, 2018. A4793 the Functionof B Cell Activating Factor Receptor in Immune Response of Pneumocystis Carinii Pneumonia/H. A4794 Pulmonary Disease Burden in Primary Immune Deficiency Disorders from the United States Immunodeficiency Network Patient Registry/M. A4795 Non-Infectious Interstitial Lung Disease After Allogeneic Hematopoietic Stem Cell Transplantion/L. A4796 Characterization of Lung Disease in Autosomal Dominant Hyper IgE Syndrome/K. A4797 P876 P866 P867 Clinical Characteristics of Antinuclear Andibody-Positive Sarcoidosis/M. A4801 Cardiac Manifestation of Sarcoidosis: A Report of a Specialized Sarcoidosis Center/O. A4803 Concurrent Gastrointestinal Involvement in Patients with Pulmonary Sarcoidosis/G. A4804 Extrapulmonary Sarcoidosis: Clinical Features and Response to Management Response to Management/P. A4808 An Exome Sequencing Study Deciphers Rare Genetic Variants in Familial Sarcoidosis/A. A4809 A Transcriptomic Analysis of Monocyte Subsets and Their Roles in Pulmonary Sarcoidosis/S. A4811 Veterans with Pulmonary Sarcoidosis Have Different Metallomic Profile Compared to Civilians with Pulmonary Sarcoidosis/C. A4812 Relationships Between Symptom Burden and Peripheral Blood Gene Expression in Sarcoidosis/V. A4813 High T-bet Expression in Peripheral T Helper Cells Correlates with Pulmonary Function Change in Sarcoidosis/N. Discussion: 11:15-12:00: authors will be present for individual discussion 12:00-1:00: authors will be present for discussion with assigned facilitators Facilitator: W. A4798 Transcriptomic Analysis of Peripheral Blood Mononuclear Cells in African Americans with Sarcoidosis/C. A4799 Peripheral Autophagy and Apoptosis Elements Distinguish Sarcoidosis and Tuberculosis/C. A4800 P886 P885 P887 P874 P888 P875 P889 the information contained in this program is up to date as of April 16, 2018. A4815 Microbiota and Clinical Variable Associations in Alpha-1 Antitrypsin Deficiency and Sarcoidosis/K. A4819 Weighted Gene Co-Expression Network Analysis of Bronchoalveolar Lavage Cells Transcriptome Identifies New Molecular Endotypes in a Large Cohort of Subjects with Sarcoidosis/M. A4821 Expression of Toll-Like Receptor 2 and 4 in the Alveolar Macrophages of Interstitial Lung Diseases/T. A4822 P2 Adult Asthma Management Resources and Pathway Implementation in Ontario Emergency Departments/C. A4826 Performance of the Asthma Impact on Quality of Life Scale in Diverse Asthma Research Samples and Demographic Sub-Groups/S. A4827 Features of Long-Term Dynamics of Health-Related Quality of Life in Patients with Asthma/J.

A7575 115 802 116 803 117 804 118 805 119 806 120 807 121 122 809 123 124 the information contained in this program is up to date as of April 16 diabetes diet oranges discount 16mg duetact visa, 2018 diabetes type 2 medication metformin side effects best duetact 17mg. A7803 404 Ranolazine and Right Ventricular Function in Patients with Pulmonary Hypertension/Y diabetic diet without medication buy duetact 17mg with mastercard. A7587 Combination Therapy Reduces Hospitalizations in Patients with Pulmonary Arterial Hypertension/C metabolic disease zombies order 16mg duetact otc. A7588 Never Too Old: Safety and Tolerability of Pulmonary Artery Vasodilator Therapies in Octogenarians and Nonagenarians/D. A7589 Intravenous Iron Substitution Improves Pulmonary Diffusion Capacity in Patients with Iron Deficiency and Pulmonary Hypertension/D. A7592 Pulmonary Artery Endovascular Device to Improve Vascular Compliance in Pulmonary Hypertension/I. A7581 Novel Analysis of Treprostinil Dose-Response Relationship Using Weight-Normalized Dosing/G. A7605 Dissecting the Molecular Effects of Cigarette Smoke on Proteasome Function/S. A7606 Cigarette Smoke Increases Severity of Influenza A Viral Infection and Impairs Epithelial Antiviral Responses in a Mouse Model/P. A7608 Cigarette Smoke Exposure Alters the Airway Epithelial Cell Fate by Modulating Mitochondrial Morphology and Bcl-2 Levels/H. A7609 Vitamin C Attenuates Endothelial Permeability Triggered by Cell-Free Hemoglobin/J. A7610 Nanoparticles Targeted to Pulmonary Intravascular Leukocytes for the Early and Specific Detection of Acute Respiratory Distress Syndrome/J. A7611 Cystic Fibrosis Transmembrane Conductance Regulator Potentiation as a Therapeutic Strategy for Pulmonary Edema: A Proof-of-Concept Study in Pigs/X. A7612 Stromal Derived Factor-1 Is Important for Mesenchymal Stromal Cell Function: Impact on Cell Response During Sepsis/M. A7613 Human Alveolar-Like Macrophages Derived from Embryonic Stem Cells for the Treatment and Prevention of Lung Disease/S. A7614 Nosocomial Lung Infection Induces a Pulmonogenic Prionopathy that Disrupts the Endothelial Barrier of the Brain/S. A7615 Lung Infection Elicits Endothelial Amyloids with Distinguishable Antimicrobial and Cytotoxic Properties/S. A7595 Dissecting the Role of Pulmonary Neuroendocrine Cells in Lung Immune Responses/X. A7596 Changes in Airway Platelet Population and Morphology in a Murine Model of Lung Fibrosis/R. A7598 the Role of Autophagy Proteins in Mesenchymal Stromal Cell Therapy During Oxidative Stress and Sepsis/S. A7601 Adult Monocytes Protect Juvenile Mice from Influenza A Virus-Induced Lung Injury/B. A7602 Nrf2 Promotes Recovery from Ischemia-Reperfusion Injury After Lung Transplantation/T. A7603 916 917 902 903 918 904 919 905 920 906 907 921 922 908 923 909 the information contained in this program is up to date as of April 16, 2018. A7618 Genetic Variation in Surfactant Protein-A2 Differentially Mediates Responses to Ozone/W. A7619 1009 925 Isolation, Reactivation and Stimulation of Axonemes Extracted from Cultured Primary Human Airway Epithelial Cells/M. A7628 Study on the Role and Mechanism of Aquaporin 3 in Pulmonary Infection Caused by Pseudomonas Aeruginosa/M. A7632 Targeting Cellular Senescence Prevents Cigarette Smoke-Induced Pulmonary Emphysema/T. A7633 Lung Bioengineering and Direct Pulmonary Cell Therapy Using a Novel Airway Spray Device/S. A7636 Culture of Epithelial Cells on Unphysiological Stiff Plastic Perturbs Baseline and Glucocorticoid Induced Gene Expression/Q. A7622 Myofibroblast Differentiation Impairs Ability to Support Adult Distal Lung Epithelial Organoid Formation/J. A7625 the E-Cigarette Flavoring Cinnamaldehyde Suppresses Mitochondrial Function and Transiently Impairs Cilia Beat Frequency in Human Bronchial Epithelial Cells/P.

Other factors may contribute to heat exhaustion diabetic nutrition cheap 16mg duetact mastercard, including obesity diabetes mellitus pronounce order duetact 17 mg with amex, crowding diabetes feet quality duetact 17mg, inadequate ventilation metabolic disease specialist colorado discount 17mg duetact visa, and shade. Guinea pigs suffering from heat exhaustion typically present with weakness, decreased mental status, ptyalism, and panting. Scorbutitis is caused by a vitamin C deficiency and is often referred to as a condition known as "scurvy. Most guinea pig diets contain vitamin C; however, improper food storage and handling may reduce the amount of vitamin C in the formula. There may be accompanying edema, anorexia, and decreased activity level and ambulation. Vitamin C also plays a role in the coagulation cascade, thus bleeding may be a presenting complaint. Sick guinea pigs should receive ascorbic acid (vitamin C) supplementation whenever in hospital. Cervical lymphadenitis, or "lumps," usually occurs when food has injured the mouth or penetrated the skin near the submandibular lymph nodes while eating. Respiratory involvement results in ocular and nasal discharge, dyspnea, and potentially, cyanosis. Guinea pigs with inadequate diet, husbandry, or environmental stress are at risk for bacteria invading the reparatory system, causing infection and potentially pneumonia. Clinical signs are similar to small animal with nasal and ocular discharge, sneezing, coughing, loss of appetite, lethargy, and labored breathing. If an inner ear infection is involved, ataxia and vestibular signs may be present. Type of bacteria which contribute to respiratory disease of guinea pigs includes Klebsiella, Bordetella bronchiseptica, Pseudomonas aeruginosa, Staphylococcus species, and Streptococcus species. Dystocia in guinea pigs most commonly results from pelvic anatomical changes which occur if females are not bred at a young age. Guinea pigs bred for the first time over 7 months of age will inevitably suffer from dystocia due to the inability of the pelvis symphysis to widen for parturition (Hoefer 2001a,b,c,d,e). Other contributors to dystocia include uterine inertia, uterine prolapse, metabolic disturbances, and toxemia. Obesity and inadequate diet may contribute to toxemia and ketosis in the pregnant sow. This condition is more commonly seen in stressed, heavily pregnant sows that are 56 days or more into gestation and are carrying 3 or more fetuses. Clinical pathology findings include hypoglycemia, hyperkalemia, elevated hepatic enzymes, hyperlipidemia, ketonemia, anemia, thrombocytopenia, and proteinuria. Although the prognosis is poor, treatment with intravenous fluids, dextrose supplementation, systemic antibiotics, and possible corticosteroids should be tried. Grasping by the base of the tail may be used as an initial means of capture and restraint until the scruff can be handled. Many pet owners will find red or red-brown spots in the cage or food dishes and fear their pet is bleeding. The discoloration is referred to as "red tearing" or chromodacryorrhea, which can also be seen at the nostril and eye, as it is a normal naso-ocular secretion. Respiratory infection causing sneezing, coughing, ataxia, chromodacryorrhea and labored breathing in rats and mice may be caused by Mycoplasma spp. Large overgrown tumors and subsequent ulceration are a common cause of presentation to the emergency room. As there are both benign and malignant tumors which affect mice and rats, surgical removal and histopathology is indicated for definitive diagnosis and prognosis. Common venipuncture sites in the rat or mouse include the orbital sinus, facial, saphenous, or the tail vein. Like rabbits and other rodents, rats and mice do not require fasting before anesthesia (Table 17. Additionally, unlike rats and mice, hamsters do not possess a tail vein as a potential venipuncture site. Alternative sites include the orbital venous sinus, jugular, and lateral marginal vein of the tarsus.

Immune system complications include decreased wound healing and increased risk of infection diabetes symptoms eye twitch order duetact 16 mg visa. Coagulation abnormalities are of serious concern but may be potentially missed in clinical practice as coagulation tests are run in vitro at body temperatures of 98 diabetes mellitus birth defects order duetact 17mg line. Coagulopathy and thrombopathia are of serious concern in patients at risk for hemorrhage diabetes diet indian food list discount 16 mg duetact free shipping, but fortunately diabete 096 cheap duetact 16mg with visa, these are reversible. Platelet function and coagulation factor function return to normal as the patient returns to normothermia. Perioperative Hypothermia Hypothermia resulting from anesthesia and surgery is of special concern and constitutes special pathophysiology. The initial phase is a heat loss caused by rapid redistribution of heat from the core to the periphery. This heat redistribution is caused by vasodilation, from anesthetic agents, and resetting of the temperature threshold needed to cause reflex vasoconstriction. The second phase of perioperative hypothermia results from excessive heat loss, not matched by heat production. Heat loss is caused by the patient losing heat on a cold table (conduction), and exposure of bodily fluids and cavities. The last phase occurs after prolonged anesthesia and results in reflex vasoconstriction initiating a plateau in temperature. Continued temperature decreases occur as a result of a decreased sympathetic response. Rewarming Therapies for rewarming strongly depend on the severity of the hypothermia and the clinical signs it may be causing. Passive rewarming consists mainly of external covers, such as blankets, bubble wrap, or foil (Kirby et al. This type of rewarming allows direct transfer of heat from the heat-generating device, such as hot water bottles, heating pads, heat lamps, or forced air warmers, to the patient. These are best used when placed on or near areas with a large blood supply such as the neck or abdomen. Barriers should be placed between the patient and the heat-generating device, if there is concern for burn injury. Heat devices that may cause burn injury include hot water bottles, heating blankets/pads, or heating disks. Warmed enemas and bladder lavage, however, may be of little benefit as there is concern as to the limited surface area of these structures. Consequences of Rewarming Rewarming is not a benign thing, and the veterinary technician should be ready to anticipate complications associated with rewarming. Second, rewarming shock is a phenomenon that patients may experience as a result of rewarming. This vasodilation has the potential to negatively impact organ perfusion and oxygen delivery to tissues during the rewarming period. Fever Hyperthermia represents an elevated core body temperature above accepted reference ranges for that particular species (Silverstein and Hopper 2009). Fever corresponds to the specific patient population that has had its thermoregulatory set point increased to meet some physiologic demand. True fever is a response of the body to invasion or injury, from pathogenic or nonpathogenic molecules that have the ability to induce fever, known as pyrogens. Most pyrogens are pathogenic; however, some pharmacologic agents, and sterile tissue inflammation and necrosis, may also cause fever. Exogenous pyrogens have the ability to release endogenous pyrogens, which act directly on the thermoregulatory center.